Preparation and application of macrolide compound

The invention relates to a macrolide compound as well as a preparation method and application thereof, in particular a modified ivermectin derivative as well as a preparation method and application thereof. General formulas (I) (II) of the compound of the macrolide derivative and salt thereof are as shown in the specification. The compound disclosed by the invention is efficient, safe, stable, wide in spectrum and low in toxicity, and has an excellent agricultural insecticidal and acaricidal activity as well as an activity of killing parasites of domestic animals and medical uronema, wherein n represents 0, 1, 2, 3, 4, 5, 6 or 7; X is either N or O; Y represents Cl ; Z is either N or O; R1 and R2 are selected from H and C1-C4 alkyl; or ZR1R2 is selected from the following structures as shown in the specification.