PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel [18]F-labeled biotin derivative.

Takashi Kudo,Masashi Ueda,Hiroaki Konishi,Hidekazu Kawashima,Yuji Kuge,Takahiro Mukai,Azusa Miyano,Shotaro Tanaka,Shinae Kizaka-Kondoh,Masahiro Hiraoka,Hideo Saji

PET imaging of hypoxia-inducible factor-1-active tumor cells with pretargeted oxygen-dependent degradable streptavidin and a novel [18]F-labeled biotin derivative.

2011

Takashi Kudo
Masashi Ueda
Hiroaki Konishi
Hidekazu Kawashima
Yuji Kuge
Takahiro Mukai
Azusa Miyano
Shotaro Tanaka
Shinae Kizaka-Kondoh
Masahiro Hiraoka
Hideo Saji

Purpose We aimed to evaluate the feasibility of using streptavidin–biotin-based pretargeting for positron emission tomography (PET) imaging of hypoxia-inducible factor (HIF)-1-active tumors.

Keywords:

Medicine
Biotin
Nuclear medicine
Positron emission tomography
Oxygen
Pretargeting
Streptavidin
Hypoxia-Inducible Factor 1
Molecular biology
Tumor hypoxia
tumor cells

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