Effect of Detailed Titration Instructions on Time to Hemodynamic Stability in ICU Patients Requiring Norepinephrine

Background This study was conducted to assess the effect of titration instructions on patients receiving norepinephrine. Methods In a single-center, retrospective cohort of patients who received at least 24 hours of norepinephrine as their first vasopressor ( n = 1,303), patients were classified by whether they received norepinephrine before ( n = 616) or after ( n = 687) titration instructions were added. Results Patients in the two groups had significant differences at baseline. On univariate analysis, time to hemodynamic stability was significantly longer in the post group (32 minutes [interquartile range (IQR): 12–65] vs. 10 minutes [IQR: 0–26]; p p = 0.02). Conclusion In this evaluation, time to hemodynamic stability was significantly longer after addition of norepinephrine titration instructions even when accounting for differences in baseline characteristics.