The effect of aureomycin and chloramphenicol on the fungal and bacterial flora of children.

SEVERAL reports in the literature have suggested that chloramphenicol and aureomycin commonly have undesirable side effects, especially involving the mucous membranes.1 2 3 These include glossitis, stomatitis, sore throat, proctitis, pruritus vulvae and and, nausea, vomiting, diarrhea, bronchomoniliasis, mycotic endocarditis and meningitis, and the sprue syndrome.4 5 6 7 8 Oral manifestations alone have been recorded in 6 to 20 per cent of patients who received aureomycin or chloramphenicol.1 Nearly all the patients in whom these complications occurred have been adults who had received relatively long-term therapy. The explanations for these phenomena vary. One hypothesis advanced suggests that they are a direct result of increased growth . . .