MRL/lマウスにおける自然発症腎炎に及ぼすMS-932の効果

We examined the effect of MS-932 (p-acetylaminophenylacetic acid) on the development of glomerular lesions and lymphoma for which abnormalities of immunological functions are responsible in MRL/l mice. MS-932 was administered orally 6 times a week from 8 to 20 weeks of age. MS-932 at doses of 3, 10, 30 and 100mg/kg suppressed the development of proteinuria, and at a dose of 3mg/kg, it lowered the level of increased BUN. MS-932 at doses of 1, 3, 30 and 100mg/kg suppressed the spontaneous production of antidsDNA antibodies in the serum. By the histopathological examination of kidneys, it was found that MS-932 at doses from 1 to 100mg/kg reduced the glomerular lesions. The immunofluorescence studies revealed that IgG deposition in the glomerular capillary membrane and mesangium was slightly reduced by the treatment of MS-932. Furthermore MS-932 at doses of 1, 10 and 30mg/kg suppressed the enlargement of cervical lymph nodes. Such effects caused by MS-932 might be due to the results of the improvement of disordered immunoregulatoly system in MRL/l mice.