A bicyclic cispentacin derivative as a novel reverse turn inducer in a GnRH mimetic.
2002
A cispentacin-derived bicyclic β-amino acid (Bic) has been synthesized and incorporated into the 6-position of GnRH. The new GnRH analogue has been characterized with respect to its structure in solution and its activity and affinity toward the human GnRH receptor.
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