Role of Mechanics in Rhythm Disturbances in 1D Mathematical Model of Myocardial Tissue with Local Ca2+-Overload

Possible contribution of the mechanics to the arrhythmogenesis in Ca2+ overloaded cardiomyocytes has been under appreciated. Earlier developed mathematical model of cardiomyocyte electromechanical function predicted a significant role of intra- and extracellular mechanical factors in triggering rhythm abnormalities.