New ripasudil hydrochloride hydrate eye drop and preparation method thereof

The invention discloses a new ripasudil hydrochloride hydrate eye drop and a preparation method thereof. The preparation method comprises: dissolving ripasudil hydrochloride hydrate and a relevant auxiliary material in water, adding a swollen sodium hyaluronate aqueous solution into the medicine solution, uniformly stirring, adding water to achieve the sufficient amount, filtering, and sub-packaging to obtain the product. The invention provides the new ripasudil hydrochloride hydrate eye drop and the preparation method thereof, wherein the defect of the existing ripasudil hydrochloride hydrate eye drop is overcome, the residence time of the medicine on the eye surface is prolonged through the physical thickening effect and the moisturizing lubrication effect of sodium hyaluronate, and the medicine does not easily flow into the mouth and the nasal cavity so as to reduce the drug loss, avoid the bitter taste of the ripasudil hydrochloride hydrate eye drop, improve the patient compliance, and ensure the clinical treatment effect.