Hypersensitivity to an oestrogen-progesterone preparation and possible relationship to autoimmune progesterone dermatitis and corticosteroid hypersensitivity

The cause of autoimmune progesterone dermatitis (AIPD) is unknown. It has been postulated that it may present a unique type of corticosteroid hypersensitivity. We report the case of a 68-year-old woman who had suffered for years from AIPD and corticosteroid sensitivity. For late menopausal syndrome she took an eostrogenprogesterone preparation (Pre-maril Plus, Dexxon) and a few days later she again developed AIPD. In our opinion this case clearly demonstrates the relationship between AIPD and corticosteroid hypersensitivity.