P69. Targeting naturally presented, leukemia-derived HLA ligands with TCR-transgenic T cells for the treatment of therapy refractory leukemias

Background T cells have proven to be effective for the treatment of leukaemias in form of donor lymphocyte infusions (DLI). However, those DLI are of unknown specificity and often associated with graft versus host disease. New effector tools in form of T cell receptor (TCR)-transgenic T cells with specificity for leukaemia-derived human leukocyte antigen (HLA) ligands are highly promising tools for the treatment of life-threatening, therapy refractory leukaemias.