Organocatalytic Asymmetric Synthesis of Trifluoromethyl‐substituted Diarylpyrrolines: Enantioselective Conjugate Cyanation of β‐Aryl‐β‐trifluoromethyl‐disubstituted Enones
2012
: Ether way: the cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy analogues.
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