Porcine urinary bladder matrix: a retrospective study and establishment of protocol

Objective: To summarise our experience with porcine urinary bladder matrix extracellular matrix (UBM) for the treatment of diabetic, venous, ischaemic or decubitus ulcerations and to outline appropriate protocol for its application. Method: A retrospective review was also conducted on all patients who received UBM (MatriStem; ACell, Inc.) from January to December 2011. Information regarding patient demographics, wound aetiology and location, as well as any prior treatments and follow-up data, were collected and reviewed from patients’ medical records. Results: Thirty-four patients were evaluated for this study. Mean patient age was 62.4 ± 13.4 years (range 29–88 years) and 76% (n=26) were male. The most common comorbidities were peripheral neuropathy (n=20), diabetes mellitus type 2 (n=19) and hypertension (n=13). Mean wound duration prior to UBM application was 25.5 ± 43.5 weeks, and mean time to healing following initial application was 9.8 ± 9.3 weeks. All patients treated with UBM progressed to full h...