Designing and testing single tablet for tuberculosis treatment through electrospinning

Abstract Drug delivery systems refers to systems designed to transport or deliver drugs to treat a certain infected organ. Generally, these systems include loading of the drug and effective substances on a carrier (nanofibers, nanoparticles, nanorods, capsule, or matrix) and delivering these substances to the infected organs. The drugs can be used in the form of dispersion, emulsion, bandages, gels, creams, or as tablets. Developing controllable drug delivery systems allow them to be utilized in wide medical applications as wound dressings, skin treatments, or to treat internal infected organs. In this work, tuberculosis drugs (pyrazinamide, isoniazid, clarithromycin, and streptomycin) are loaded on poly(e-caprolactone), poly(ethylene oxide), and poly(vinyl alcohol) nanofibers to design single tablets suitable for HIV patients. The activity of these drugs loaded on the nanofiber is tested against Mycobacterium avium through broth dilution assay and by agar plate assay. The minimal inhibitory concentration and the minimal bactericidal concentration are also studied.