Abstract 14532: Serine Mutations in Hsp27 Abrogate Its Ability to Inhibit p53 Dependent Apoptosis and Doxorubicin-Induced Heart Failure in Mice

Ragu Kanagasabai,Krishanamurthy Karthikeyan,Jay L. Zweier,Govindasamy Ilangovan

Abstract 14532: Serine Mutations in Hsp27 Abrogate Its Ability to Inhibit p53 Dependent Apoptosis and Doxorubicin-Induced Heart Failure in Mice

2019

Ragu Kanagasabai
Krishanamurthy Karthikeyan
Jay L. Zweier
Govindasamy Ilangovan

Rationale: Small heat shock proteins (sHsps) protect the heart from chemotherapeutics-induced heart failure, by inhibition of p53-dependant apoptosis. However, mechanism of such protection has not ...

Keywords:

Cardiomyopathy
Cardiology
Cancer research
Diabetes mellitus
Hsp27
Internal medicine
Apoptosis
Ventricular remodeling
Medicine
Heart failure
Doxorubicin
Serine

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