Security Research on Mice by Feeding on 2 Bacillus Strains

[Objective] The research investigated the security of 2 Bacillus strains in order to lay the foundation for the further development of probiotic additives.[Method] Using the Bacillus strains L2-19 and Y25 as tested materials and the healthy white mice as tested animals,the security experiments on strains were made through 2 ways of pouring into stomach through mouth and injecting in the abdomen.[Result] All the white mice survived healthily after treatment and their body weight increased obviously.After treatment by gavage,the body weight of the white mice in the experimental group L2-19 and Y25 and the control(saline) increased 5.06 g,4.92 g and 5.04 g resp.than that before the treatment and after intraperitoneal injection,the body weight increased 5.38 g,4.96g,4.80 g, resp.than that before the treatment.The viscera of the white mice in the experimental group were no obvious abnormality and the organ coefficient had no significant difference between the experimental group and the control group(P0.05).There was no toxicity reaction to be found.[Conclusion] The Bacillus strains L2-19 and Y25 were safe and innocuity to the white mice and could increase the body weight of the white mice,so they had further developmental value to become probiotic additives.