To: CC: Date: From: Subject: CN=KristineHealey/OU=AM/0=LLY@Lilly

Gluconeogenesis is the process by which the liver makes glucose by breaking down glycogen. Gluconeogenesis is prevented by insulin, and therefore occurs in insulin deficient or relative insulin deficient states. We know, thanks to the hyperglycemic clamp study, that Zyprexa does not affect the pancreas's ability to secrete insulin. We do not know for certain that Zyprexa is not associated with increased insulin resistance. The claim the DM wishes to make cannot be made with certainty.