Diego and friends play again.

The formation of properly differentiated organs often requires the planar coordination of cell polarization within the tissues. Such planar cell polarization (PCP) events are best studied in Drosophila, where many of the key players, known as PCP genes, have already been identified. Genetic analysis of the PCP genes suggests that the establishment of polarity consists of three major steps. The first step involves the generation of a global polarity cue; this in turn promotes the second step, the redistribution of the core PCP proteins, leading to the formation of asymmetrically localized signaling centers. During the third step, these complexes control tissue-specific cellular responses through the activation of cell type specific effector genes. Here we discuss some of the most recent advances that have provided valuable new insight into each of the three major steps of planar cell polarization.