Comparison on dosage and effect of postoperative analgesia between patients of Uygur and Han nationalities after spinal surgery

Objective To compare dosage and effects of postoperative analgesia between patients of Uygur and Han nationalities after spinal surgery.Methods Ninty-four ASA Ⅰ or Ⅱ patients(47 Uygur nationality,47 Han nationality) undergoing posterior laminectomy,discectomy interbody pedicle fixation operation under general anesthesia were divided into two groups (U and H).The patients in both groups received fentanyl patient-controlled intravenous analgesia after surgery.Visual analog scale (VAS),Ramsay sedation scale score,the vital signs at 6,12,24,48 h after operation and the total consumption of fentanyl,the total number and the valid number of pressing patient-controlled analgesia (PCA) pump,the adverse effects at 48 h after operation were recorded and compared.Results There were no difference in the mean artery pressure (MAP),pulse oxygen saturation(SpO2),Ramsay score and VAS score at the time points of patients between two groups (P＞0.05).The total consumption of fentanyl,the total number and the valid number of pressing PCA pump (times) in group U were (1 203±217) pg,(21.8±6.8),(13.2±3.0) respectively.It was significantly higher than those of group H,which were (793±138) μg,(12.5±3.2),(7.9±2.6) respectively.Compared with group H (15％),the occurrence rate of postoperative nausea and vomiting in group U (27％)was significantly higher (P＜0.05).Condusions There is a significant difference in the total consumption of fentanyl between Uygur and Han nationalities.The influence of nationality on recommended dosage of fentanyl should be considered. Key words: Race;  Fentanil ;  Postoperative analgesia