EFFICACY OF EUPHORBIA THYMIFOLIA LINN PHYTOSTEROL ON ROTENONE INDUCED PARKINSON'S DISEASE: BEHAVIOURAL AND NEUROCHEMICAL STUDY

P revious works showed antianxiety, antidepressant and nootropic activity of E. thymifolia total sterol (ETTS) with facilitatory effect on retention of acquired learning and memory. This has driven to explore neurorejuvenating potential of ETTS against rotenone induced parkinson’s disease (PD) by assessing behavioral and neurochemical alterations on mice. The present experiment was designed to assess effect of ETTS on behavioural dysfunction, neurochemical abnormality and oxidative stress in mice brain on rotenone induced PD model. ETTS 75 mg/kg (P < 0.01-0.001) treated group showed significant reversal of body weight loss, locomotor score, rota rod muscle grip and rearing behavior induced by rotenone . ETTS has significantly (P < 0.001) reversed the increased lipid peroxidation and declined glutathione and nitric oxide scavenging ability. Significant increase (P < 0.05-0.001) in gama amino butyric acid and dopamine level was observed in ETTS treated group whereas acetylcholine esterage level has not been changed significantly. The results substantiate protective effect of ETTS on dopaminergic neurons against degenerative effects of rotenone may be by virtue of free radical scavenging ability. S ignificant improvement in the neurobehavioral, oxidative and neurochemical parameters was observed ETTS administration along with rotenone exposure.