Total synthesis of the antimycoplasma antibiotic micacocidin
1998
Abstract A total synthesis of the antimycoplasma antibiotic micacocidin ( 1 ) is described. Construction of sterically hindered thiazoline 12 was achieved by a phosphorus pentachloride-mediated cyclization reaction of S -protected aryloylcysteine 11 , and compound 1 with desired chirality at C-10 was favorably obtained from diastereomeric mixture 30 through formation of the Zn complex 31 .
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