Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl * in girls with central precocious puberty

Objective To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels. Design Blood PRL levels were measured at 9 a.m. every 28 days for a period of 6 months. Setting Pediatric Endocrine Clinic, Hasharon Hospital, Petah Tiqva, Israel. Patients Thirteen girls with idiopathic central precocious puberty. Results Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 ± 5.6 to 21.5 ± 12.5 μ g/L (mean ± SD). Conclusions The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.