Access to Ynamides via CuO-Mediated Oxidative Amidation of Alkynes
2012
Copper(II) oxide mediated the direct coupling of terminal alkynes and amides by way of C-H functionalization to afford ynamides as useful building blocks. Some alkali halides such as KCl were discovered to play a key role as additive in the coupling reaction, while other salts could suppress the formation of products.
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