Screening of bioactive compounds from natural remedies for photoaging, to target Ap-1; an in silico approach

Although skin aging due to UV exposure (photoaging) and chronological skin aging have been thought to be distinct, photoaging has a considerable effect on chronological aging. UV irradiation of skin leads to oxidative stress and increases reactive oxygen species (ROS) and also reduces antioxidant enzyme. As a consequence, several cell surface cytokines and growth factor receptors are activated which results in recruitment of several adaptor proteins to regulate downstream signaling. AP-1 is a transcription factor which up-regulates matrix-metalloproteinases and down-regulates type 1 procollagen. Thus AP-1 can be an effective target for photoaging. In this study, the effect of 56 active ingredients from several natural and easily available traditional remedies for skin aging has been studied by means of in silico approach and the potential active ingredients have been identified.