MnO2-Catalyzed Oxidative Alkylation of Enamides with Ethers via C(sp3)–H/C(sp2)–H Cross-Dehydrogenative Coupling and Hydrolysis Sequence

A new MnO 2 -catalyzed oxidative alkylation of enamides with a C(sp 3 )–H bond adjacent to an oxygen atom is described. This method achieves a C(sp 3 )-H/C(sp 2 )-H cross-dehydrogenative coupling and hydrolysis, thus providing efficient and general access to a variety of β-oxo ketones.