Апудоциты при пролиферативных процессах эндометрия

The aim of present investigation was to study the interaction of cells APUD-systems with endometrium proliferative processes under hyperplastic processes and cancer. We examined 184 women, of which 135 patients were diagnosed hyperplastic proccesses of endometrium, 34 women had a cancer of endometriae. Evaluation of interacting apudocyte guantitative and gualitative analysis with the degree of endometrium differentiation and exchange-endocrine disturbances has been conducted. Moreover the influence of APUD-system cells on the proliferative activity was studied. It has been revealed that the number of endocrine cells increases to 24,6±2,3 under hyperplastic processes. Apudocyte content was 105,6±12,04 in case of early cancer and 120±12,04 under terminal cancer. These data suggest, that the number of apudocytes in endometrum parenchima increased with rising degree of endometrium cancer differentiation. Analysis of interactions between apudocytes amount and exchange-endocrine distur-bances revealed that the last occurred in patients with apudocytes in endometrium in 92% of cases and without apudocytes in 51%. Moreover, it has been found connection of endometrium proliferative activity with presence of apudocytes. There was observed an enhancement of proliferative activity while deteriorating morphological reconstruction of premalignant changes of endometrium and 1,5-2-fold decrease of endometrium apudocytes number in women had apudocytes in endometrium.