PDMS Microfluidic Device with an Integrated Optical Sensor for Determination of Zinc (II) in Pharmaceuticals: Toward the Production of Miniaturized Green Chemistry Analytical Systems

ABSTRACT A simple miniaturized system was fabricated in general laboratory from polydimethylsiloxane (PDMS) according to a prototype casting and molding process permitting the construction of three-dimensional (3D) microchannel (100 µm i.d.) with T-type network, together with an integrated optical sensor for on chip detection. The fabricated device has been successfully applied as a green chemistry-compatible miniaturized analytical system for the determination of zinc (II) in pharmaceutical samples taking the advantage of the colorimetric reaction of zinc (II) and xylenol orange in acetate buffer at pH 5.5. The microfluidic device is a convenient way to quantify zinc (II) over a wide dynamic range, 0.2–2.5 µg mL−1, with good linearity (R2 0.9940).