A rational eco-compatible design strategy for regio- and diastereoselective synthesis of novel dispiropyrrolidine/thiapyrrolizidine hybrids
2015
A facile regio- and stereoselective synthesis of novel dispiroheterocyclic hybrids containing benzo[1,4]oxazine/benzo[1,4]thiazine and pyrrolidine/thiapyrrolizidine moieties via 1,3-dipolar cycloaddition reaction was carried out. The reaction has been carried out using 2,2,2-trifluoroethanol as a new alternative green solvent and catalyst for rapid access to construct a diversity-oriented library of regioselectivity dispiropyrrolidine/thiapyrrolizidines. Mild reaction conditions with excellent conversion, higher yields in shorter reaction times and the easy recyclability of 2,2,2-trifluoroethanol makes this protocol attractive, sustainable and environmentally benign.
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