In vitro effects of vasoactive intestinalpolypeptide on guinea pig urinary bladder

Abstract Vasoactive intestinal polypeptide (VIP) may have a neuronal function regulating smooth muscle activity. At concentrations ranging from 0.25 to 3.0 μ g/ml VIP elicited no significant changes in baseline tension, magnitude, or frequency of contractions of guinea pig bladder muscle strips. Likewise, VIP did not inhibit significantly the rise in baseline tension elicited by acetylcholine or electrical stimulation.