Ventilatoy-associated pneumonia in pediatrics: characteristics of pathogens and strategies for anti-infections.

OBJECTIVE To explore the characteristics of the pathogens of ventilatoy-associated pneumonia(VAP) in pediatrics and the strategies for anti-infections.METHODS Among 68 pediatrics patients with VAP in intensive care unit(ICU) in hospital,the lower respiratory tract secretions were cultured and analyzed.RESULTS Among 81 strains of isolated pathogens in 68 patients,the Gram-negative bacteria accounted for 85.2%,the Gram-positive bacteria for 8.6% and the fungi for 6.2%.The predominant pathogens were Acinetobacter baumannii,Stenotrophomonas maltophilia,Enterobacter cloacae,Klebsiella pneumoniae and Escherichia coli.The Gram-negative bacteria were only sensitive to piperacilin/tazobactam and imipenem/cilastatin(except S.maltophilia) and highly resistant to other common antibiotics.The Gram-positive bacteria were drug resistant to penicillins and β-lactam antibiotics.Vancomycin-resistant Staphylococcus aureus were not detected out.CONCLUSION The predominant pathogens of VAP in pediatrics are the Gram-negative bacteria and multi-drug resistant.Empirical antibacterial therapy and objective antibacterial therapy for patients with VAP are very important.