P148 Correlating changes in lung function with patient reported outcomes in COPD

Introduction Relationships between improvements in lung function and other outcomes in COPD patients are not documented extensively. We examined the association between changes in FEV 1 and patient-centred outcomes using pooled data from three indacaterol studies. Methods We calculated correlations between changes in Transition Dyspnea Index (TDI) and St. George9s Respiratory Questionnaire (SGRQ) scores (at 12, 26 and 52 weeks) and exacerbation frequency (rate/year) across five categories of ΔFEV 1 with boundary points (in mls) between categories: –500 (lowest value), –50, +50, +150, +250, +500 (highest value), centred at –275, 0, 100, 200 and 375 ml. We also performed generalised linear modelling adjusting for covariates including baseline severity, treatment and ICS use. Results 3313 patients with non-missing values of relevant variables were analysed, excluding extreme values of ΔFEV 1 (outside ±500 ml). TDI and ΔSGRQ at 12 weeks improved and exacerbation rate declined with increasing positive ΔFEV 1 (all p 1 and outcomes. Conclusions These results suggest that larger improvements in FEV 1 with long-acting bronchodilator therapy are likely to be associated with larger patient-centred benefits across a range of outcomes.