Effect of sex on early surgical outcomes of isolated coronary artery bypass grafting

Amac: Bu calismada cinsiyetin izole koroner arter baypas greftlemenin (KABG) erken cerrahi sonuclari uzerindeki muhtemel etkileri arastirildi. Ca­lis­ma­ pla­ni:­ Kalp hastalarini kapsayan mevcut veri tabaninin retrospektif incelemesine, Agustos 2007 ve Mart 2011 tarihleri arasinda Iran, Tahran Shariati Hastanesi’nde izole KABG yapilan 1390 ardisik olgu (393 erkek, 997 kadin; ort. yas 58.7±10.1 yil; dagilim 23-87 yil) alindi. Erkek ve kadin cinsiyetleri ameliyat oncesi ozellikler acisindan karsilastirildi. Cinsiyetin ameliyat sonrasi mortalite ve morbidite uzerindeki muhtemel etkilerini degerlendirmek uzere basamakli cok degiskenli lojistik regresyon analizi yapildi. Bul gu lar: Kadin hastalarin yasi daha ileriydi ve diabetes mellitus, hipertansiyon, hiperkolesterolemi ve hiperlipidemi prevalansi daha yuksekti. Mortalite orani, erkeklere kiyasla, kadinlarda anlamli duzeyde daha yuksekti (%2.3’e kiyasla %6.9; p<0.001). Kadin cinsiyeti ameliyat sonrasi mortalite, septisemi, uzamis mekanik ventilasyon, bacaklarda enfeksiyon ve renal komplikasyonlarin bagimsiz bir ongordurucusuydu. So­nuc:­ Calisma bulgularimiz, kadin cinsiyetinin ameliyat sonrasi mortalite ve bazi morbiditelerin bagimsiz bir ongordurucusu oldugunu gostermektedir. Bu nedenle, izole KABG yapilan kadin hastalara ozel ihtimam gosterilmelidir. Anah tar soz cuk ler: Koroner arter baypas greftleme; morbidite; mortalite; ameliyat sonrasi; cinsiyet. Background:­In this study, we investigated possible effects of sex on early surgical outcomes of isolated coronary artery bypass grafting (CABG). Methods: In this retrospective review of existing database including patients with heart disease, 1,390 consecutive cases (393 males, 997 females; mean age 58.7±10.1 years; range 23 to 87 years) who underwent isolated CABG in Shariati Hospital, Tehran Iran between August 2007 and March 2011 were recruited. Male and female sexes were compared for preoperative characteristics. A stepwise multivariate logistic regression analysis was performed to evaluate possible effects of sex on postoperative mortality and morbidity. Results:­ Female patients were older with a higher prevalence of diabetes mellitus, hypertension, hypercholesterolemia and hyperlipidemia. The mortality rate was significantly higher in women compared to men (6.9% vs. 2.3%; p<0.001). Female sex was an independent predictor of postoperative mortality, septicemia, prolonged mechanical ventilation, leg infection, and renal complications. Conclusion:­Our study results show that female sex is an independent predictor of postoperative mortality and some of morbidities. Therefore, specific attention should be warranted to female patients undergoing isolated CABG.