Use of trimethoprim–sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study

Aims Data available on the fetal safety of trimethoprim–sulfamethoxazole (TMP‐SMX) exposure during pregnancy remains scarce and inconclusive. A previous study assessing the link between TMP‐SMX exposure during pregnancy and the risk of spontaneous abortion (SA) did not control for protopathic bias and indication bias.