Examination of Myc and Ras Oncogene Products P62 and P21 on Specimens of Squamous Epithelial Tumors of the Skin

With anti-myc and ras oncogene product monoclonal antibodies P62 and P21,27 cases of squamous epithelial tumors of the skin (SETS) specimens were examined.The results showed that 62.9%(17/27) and 66.7%(18/27) of the specimens expressed P62 and P21 proteins respectively.Thirteen specimens expressed P62 and P21 proteins simultaneously.The results also showed that P62 was mainly seen in the poorly differentiated squamous cell carcinoma specimens,while P21 was mainly in the relatively well-differentiated specimens.The authors consider that myc and ras oncogenes might have different effects on the develpment of the SETS,and their synergy might be associated with the persistant growth of SETS. Key words: Oncogene Squamous epithelial tumors; Skin neoplasms