Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

Abstract Novel 2-imidazoles have been identified as potent partial agonists of the α 1A adrenergic receptor, with good selectivity over the α 1B , α 1D and α 2A receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.