gem-Heteroatom-substituted fluoroalkenes as mimics of amide derivatives or phosphates: a comprehensive review
2021
gem -Heteroatom-substituted fluoroalkenes have received little attention despite their great potential in medicinal chemistry or in fine chemistry. Indeed, due to the electronic and steric similarity between fluoroalkene moiety and amide bond as well as the high strength of carbon-fluorine bond, these gem -heteroatom-substituted fluoroalkenes could be envisioned as stable mimics of various important organic functions such as phosphates, carbamates, S-thiocarbamates and ureas. We present herein an overview describing the syntheses over the last decade of heteroatom-substituted fluoroalkenes in geminal position. This review will be divided into several sections covering each the common following heteroatom: Oxygen-, Nitrogen-, Sulfur-, Phosphorus-, Boron- and Silicon- substituted fluoroalkenes.
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