Abstract 16897: Morphologic and Functional Assessment of Coronary Artery Disease: Potential Application of CT Angiography and Myocardial Perfusion Imaging

Purpose: Now that the technological advances have substantially and favorably allowed reduction in radiation burden both from CT angiography (CTA) and myocardial perfusion imaging (MPI) by single-photon emission computed tomography (SPECT), and because CT-SPECT combination is becoming a mainstream investigative tool, we evaluated the role of combined evaluation of MPI and CTA in coronary artery disease (CAD). For CTA, we evaluated both, the extent of luminal stenosis as also the features of high-risk plaques (HRP, including positive remodeling and low attenuation. Methods: 280 patients (65±11 years, mean f/u: 26 months) underwent both CTA and MPI. Patients without significant stenosis on CTA, or suspected of stenosis by CTA but normal MPI findings were classified as normal, and patients with significant CTA stenosis and reversible defect on MPI were classified as abnormal. On CTA, HRP was also reported regardless of luminal stenosis. Patients were classified into group 1: abnormal CTA and MPI (n=81), grou...