Technetium-99m tetrofosmin scintigraphy to evaluate breast lesions.

The aim of this study is to characterise benign from malignant breast lesions by using 99mTc-Tetrofosmin. Materials: Fifteen female patients with suspected breast lesions and ten normal controls underwent breast scintigraphy with 99mTc-Tetrofosmin. All patients had conventional mammography. Breast imaging begun 20 minutes after i.v. injection of 740 MBq 99mTc-Tetrofosmin. Patients were imaged in supine and prone position. Results of the 15 patients with suspected breast lesions, 13 showed breast uptake, and 6 of them had suspicious lesions on mammography. Surgery confirmed 10 carcinomas and 3 benign lesions. Two patients demonstrated no abnormal accumulation or suspicious findings in mammography. None of the normal controls had breast uptake or mammographic abnormalities. Out study has a sensibility of 100% and 60%, and a specificity of 80% and 100% in scintigraphy and mammography respectively. Conclusion: Out findings suggest that 99mTc-Tetrofosmin may play a role in evaluating breast masses and that can differentiate benign from malignant lesions.