The Effects of Pregabalin on Cerebral Cortical Oxidative Stress of Rats on Pentylenetetrazole Induced Epileptic Seizure

Methods: Forty male Wistar rats were randomly divided into four equal groups. The first group was used as a control group. The second group received a single dose administration of PTZ. Third and fourth groups were given, via gastric gavage, doses of 100 mg/kg body weight/day of PGB, divided into two, for two days. Seizure is obtained by applying intraperitoneally (ip) 50 mg/kg body weight of PTZ to groups II and IV. After one hour of PTZ administration, all rats were sacrificed and brain cortex tissues were taken. SOD and CAT activities and NO and MDA levels were studied in the brain cortex tissues.