Antibacterial Use Density in a Hospital

OBJECTIVE To provide an evidence for rational use of antibacterials in the clinic through analysis of the antibacterial use in a hospital.METHODS By retrospective study,the data of drug used from 2004 to 2008 were collected and analyzed by Excel 2003.Taking defined daily dose(DDD) as the unit,antibacterial use density(AUD) was calculated and carried on the analysis.RESULTS The AUD was fluctuant during the last 5 years.The third generation cephalosporins,penicillin/beta-lactamase inhibitors and the second generation cephalosporins ranked in the first three places in turn.The drug ranking in the first ten places came from cephalosporins,penicillin/beta-lactamase inhibitors,nitromidazoles,and fluoroquinolones and the majority of antibacterials were injection.Comparing with the domestic and foreign hospital,AUD in the hospital was significantly lower than the average level of China's.The use of antibacterials was different from South Korea and America.CONCLUSIONS The hospital may exist such problems as overmedication,dense medication and the high use ratio of broad-spectrum antimicrobial agents.Cephalosporins,penicillin/beta-lactamase inhibitors and fluoroquinolones should be strictly limited in the clinic to avoid an excessive increase in AUD.