Palladium‐Catalyzed Glycosylation Reaction: De‐novo Synthesis of Trehalose Analogues.

The unnatural L‐1,1‐α‐disaccharides were synthesized from acylfurans using a palladium‐catalyzed glycosylation reaction. The 1,1‐α‐manno‐disaccharides were achieved in six total steps starting from an acylfuran. The overall efficiency of this protocol was the use of highly diastereoselective palladium‐catalyzed glycosylation, reduction, and dihydroxylation. This paper is dedicated to Prof. Denis W. H. MacDowell during the year of his 80th birthday.