Imipramine-responsive panic-like symptomatology in schizophrenia/schizoaffective disorder

A “panic-like” syndrome responsive to supplemental alprazolam has recently been described in schizophrenia (Kahn et al. 1987; Sandberg and Siris 1987). It is not known, however, if this condition might be responsive to treatment with other antipanic medications as well. Therefore, we report trials of adjunctive spine (IMI) in two such patients who met criteria for schizophrenia or schizoaffective disorder.