[Immunoenzyme analysis of the serological activity of the structural modifications of a synthetic antigen simulating the O-determinant 4 of Salmonellae].

: The comparison of the copolymer of 2-O-(alpha-abequosy)-alpha-alyl-alpha-mannopyranoside and acrylamide (AMA), used as a synthetic antigen, with its natural prototype, Salmonella typhimurium lipopolysaccharide, in the enzyme immunoassay (EIA) has revealed that the serological activity of AMA is related to the specific content of antigenic determinants in its molecule. The analysis of the serological specificity of AMA indicates that this specificity corresponds to factor 4 of Salmonella O-antigen. The high activity and monofactor specificity of the synthetic antigen AMA suggest that the use of this antigen in EIA as a diagnostic preparation holds good promise.