Влияние депрессии на течение ишемической болезни сердца и качество жизни пациентов

We undertook the analysis of cardiovascular risk factors and psycho-social factors in 230patients with coronary heart disease (CHD) based at a city polyclinic. Ninety (31.1%) patients suffered depression (19-28 CES-D scores). Patients with and without depression were significantly different in terms of clinical and functional manifestations of stable angina of effort, cardiovascular riskfactors, gender, and psycho-social factors. CHD with depression was associated with a higher FC of angina of effort, risk of adverse outcome (Duke index), frequency of concomitant pathology, psycho-social stress, loss of working capacity and a lower income levels. These patients treated with selective antidepressants (serotonin reuptake inhibitors) for 6 months experienced a marked decrease in the degree of depression and manifestation of its symptoms, improved psychosocial protection and quality of life compared with untreated patients. These data illustrate pathogenetic and behavioural mechanisms underlying the relationship between CHD and depression.