Monoclonal antibody and its application

The invention belongs to the technical fields of antibody drug, and in particular to mouse anti human PD-L 1 monoclonal antibody and its application.Antibody provided by the invention is derived from mouse hybridoma and by the screening of PD-L1 affinity, source of mouse antibody is excellent to the affinity and specificity of monkey PD-L1 or/and human PD-L 1, it can be in the combination of dose-dependent block human PD-L 1 and people PD-1, T lymphocyte proliferation is effectively promoted, the secretion of lymphoma cell IL-2 and IFN γ are stimulated.Anti- PD-L1 plays the effect of killing tumor cell by blocking PD-1/PD-L1 signal that can promote the proliferation of specific for tumour antigen T cell simultaneously.It blocks the treatment of PD-1 and PD-L1 signal path to walk with its good efficacy and saferry in the forefront of immunization therapy, becomes the popular target spot in nearly 2 years lung cancer therapy fields.