Toxicity of different endodontic antiseptics

: The median lethal dose (LD 50) of endodontic antiseptics sodium hypochlorite, chloramine and chlorhexidine digluconate was determined in experiment on albino mice using the method described by Litchfield and Wilcoxon. Sodium hypochlorite and chloramine have shown a twice stronger toxic effect than chlorhexidine digluconate. The difference was significant.