New aspects in pathogenesis of respiratory sarcoidosis

: A comprehensive examination was made of 101 patients with sarcoidosis of the intrathoracic lymph nodes (ITLN) (n = 33), with that of ITLN and lung (n = 47) or sarcoidosis of the lung (n = 21). Special studies were conducted to examine the pulmonary scintigraphic and X-ray pneumopolygraphic findings reflecting impaired microcirculation and biomechanics of respiration, the levels of medium-weight molecules, their fractions, and small-weight molecules in the sera and urine, which reflects the severity of endoxemia, as well as the electrophoretic motility of red blood cells which are involved in metabolism and the degree of tissue hypoxia. The findings have confirmed that there are respiratory, circulatory, and tissue hypoxias, and endogenous intoxication just in earliest respiratory sarcoidosis, which is of definite importance in the pathogenesis of the disease, allowing the use of pathogenetic agents as antihypoxants to be justified.