Clinical impact of small subclones harboring NOTCH1, SF3B1 or BIRC3 mutations in chronic lymphocytic leukemia

Large-scale sequencing approaches have shown that chronic lymphocytic leukemia (CLL) is composed of a mosaic of leukemic subpopulations, each defined by distinct genetic lesions.[1][1]–[4][2] The application of ultra-deep-next generation sequencing (NGS) to track TP53 mutated subclones in CLL has