Reductive Cleavage of the Ribose Moiety in Purine Nucleosides Using Diisobutylaluminum Hydride : A New Method for the Preparation of Acyclonucleosides.
1994
Abstract Reaction of purine nucleosides, such as 2′,3′- O - isopropylideneinosine 1a and 2′,3′- O -isopropylideneadenosine 1c , with diisobutylaluminum hydride in dry tetrahydrofuran resulted in the reductive cleavage of the ribose moiety at the anomeric position to give the corresponding 9-(2′,3′- O -isopropylideneribityl)purines 2a , c in good yields.
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