Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

Qiang Jeremy Wen,Qiong Yang,Benjamin Goldenson,Sébastien Malinge,Terra L. Lasho,Rebekka K. Schneider,Lawrence J. Breyfogle,Rachael Schultz,Laure Gilles,Priya Koppikar,Omar Abdel Wahab,Animesh D Pardanani,Brady Lee Stein,Sandeep Gurbuxani,Ann Mullally,Ross L. Levine,Ayalew Tefferi,John D. Crispino

Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition

2015

Qiang Jeremy Wen
Qiong Yang
Benjamin Goldenson
Sébastien Malinge
Terra L. Lasho
Rebekka K. Schneider
Lawrence J. Breyfogle
Rachael Schultz
Laure Gilles
Priya Koppikar
Omar Abdel Wahab
Animesh D Pardanani
Brady Lee Stein
Sandeep Gurbuxani
Ann Mullally
Ross L. Levine
Ayalew Tefferi
John D. Crispino

An inhibitor of Aurora kinase promotes megakaryocytic differentiation of cells from patients with primary myelofibrosis and shows antifibrotic effects in mouse models of this disease.

Keywords:

Immunology
Aurora Kinase A
Cell growth
Fibrosis
Cellular differentiation
Aurora kinase
Signal transduction
Janus kinase 2
Myelofibrosis
Medicine
Myeloproliferation
Ruxolitinib
symptomatic relief

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