Experimental effects of ginseng saponin in treatment of acute spinal card injury of rat

Objective: To study the effect and role of using ginseng saponin to treat spinal cord injury of rat. Methods: 60 SD-rats were divided into four groups, all rats′ spinal cord injury patterns were made by Allen′s method. Part of rat were injected with ginseng saponin and methlpredisolone (MP), at postoperative 12 h, 24 h, 7 day, 14 days, took out spinal cord to test MDA, SOD, ET and NGF; and the pathology of spinal cord was examined. Results: Injury group MDA was increased, SOD was decreased, ET was increased. The markers of treatment had ameliorated (P 0.01). Nerve cell degeneration and necrosis occured in injury groups, the injury degree decreased in treatment groups. Ginseng saponin could increase NGF and accelerate plerosis of nerve injury. Conclusions: In early period of spinal cord injury, ginseng saponin can protect spinal cord.